Nafarelin

Also known as: Synarel

HormonalFDA APPROVED

Clinical Status

FDA Approved — endometriosis, central precocious puberty.

Mechanism of Action

A potent GnRH agonist administered intranasally. Causes initial gonadotropin stimulation followed by desensitization, resulting in suppression of ovarian and testicular steroid production.

Dosing Defaults

Dose

200-400 mcg twice daily

Frequency

2x daily

Administration

Intranasal spray

Timing

Morning and evening

Food

with or without

Duration

6 months for endometriosis

Dose range: 200-800 mcg daily (intranasal)

Twice daily intranasal dosing maintains consistent hormone suppression.

Side Effects

•Hot flashes
•Nasal irritation
•Headache
•Mood changes
•Vaginal dryness
•Bone density loss

Contraindications & Warnings

⚠Pregnancy
⚠Undiagnosed vaginal bleeding

•Not medical advice
•Avoid nasal decongestants within 30 minutes

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This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.