Noopept

Also known as: GVS-111, N-Phenylacetyl-L-prolylglycine ethyl ester

CognitivePHASE 2

Clinical Status

Approved in Russia — sold as a nootropic supplement elsewhere.

Mechanism of Action

Modulates AMPA and NMDA glutamate receptors, increasing BDNF and NGF expression. Enhances long-term potentiation in hippocampal neurons. Also has mild anxiolytic and anti-inflammatory neuroprotective effects.

Dosing Defaults

Dose

10-30 mg

Frequency

2-3x daily

Administration

Oral or sublingual

Timing

Morning and early afternoon

Food

with food

Duration

1.5-3 month cycles

Dose range: 10-40 mg daily

Split dosing maintains cognitive enhancement. Avoid evening to prevent sleep disruption.

Side Effects

•Headache
•Irritability
•Insomnia
•Restlessness
•Nausea
•GI discomfort

Contraindications & Warnings

⚠Severe hypertension
⚠Severe hepatic impairment

•Not medical advice

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This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.