Pegvisomant

Also known as: Somavert

MetabolicFDA APPROVED

Clinical Status

FDA Approved — acromegaly.

Mechanism of Action

A PEGylated growth hormone receptor antagonist. Binds to GH receptors without activating them, blocking endogenous GH action and reducing IGF-1 production. Used when GH excess causes metabolic and growth abnormalities.

Dosing Defaults

Dose

10-30 mg daily

Frequency

1x daily

Administration

Subcutaneous injection

Timing

Same time each day

Food

with or without

Duration

Long-term / chronic use

Dose range: 10-40 mg daily

Consistent daily timing maintains steady GH receptor blockade.

Side Effects

•Injection site reactions
•Elevated liver enzymes
•Headache
•Diarrhea
•Nausea
•Flu-like symptoms
•Tumor growth (pituitary adenoma monitoring)

Contraindications & Warnings

⚠Hepatic impairment

•Not medical advice
•Regular liver function monitoring required
•Monitor pituitary tumor size

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This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.