Sermorelin

Also known as: Geref, GRF 1-29

Growth HormoneFDA APPROVED

Clinical Status

Previously FDA Approved (discontinued) — off-label use continues.

Mechanism of Action

Bioidentical to the active portion of endogenous GHRH. Stimulates the pituitary's natural production and release of growth hormone, maintaining normal feedback mechanisms.

Dosing Defaults

Dose

200-500 mcg

Frequency

1x daily

Administration

Subcutaneous injection at bedtime

Timing

Before bed (fasted)

Food

fasted

Duration

3-6 months

Dose range: 100-500 mcg daily

Mimics natural GHRH and works best before sleep to enhance natural nighttime GH release.

Side Effects

•Facial flushing
•Injection site reactions
•Headache
•Nausea
•Dizziness
•Joint pain
•Water retention

Contraindications & Warnings

⚠Active malignancy

•Not medical advice

Compare

Compare Sermorelin with another peptide side-by-side.

Calculate Dose

Use the reconstitution calculator to prepare your Sermorelin dose.

Open Calculator

Related Growth Hormone Peptides

Ipamorelin

PHASE 2

Growth Hormone

Selective GH secretagogue. Considered one of the safest GHRPs.

CJC-1295

PHASE 2

Growth Hormone

Synthetic GHRH analog that stimulates GH release from the pituitary.

CJC-1295 DAC

PHASE 2

Growth Hormone

Long-acting version of CJC-1295 with extended half-life via albumin binding.

Tesamorelin

FDA APPROVED

Growth Hormone

FDA-approved GHRH analog for visceral fat reduction in HIV lipodystrophy.

This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.