Argireline

Also known as: Acetyl Hexapeptide-3, Acetyl Hexapeptide-8

Skin & HairPHASE 2

Clinical Status

Cosmetic use — widely available.

Mechanism of Action

Mimics the N-terminal of SNAP-25 protein, inhibiting SNARE complex formation necessary for muscle contraction. Reduces facial muscle movement, similar to but milder than botulinum toxin.

Dosing Defaults

Dose

Topical

Frequency

2x daily

Administration

Topical (serums, creams)

Timing

Morning and evening

Food

with or without

Duration

Ongoing use

Dose range: Topical application

Twice daily application maintains peptide concentration at the skin surface.

Side Effects

•Mild skin irritation (rare)
•Redness or tingling (rare)

Contraindications & Warnings

•Not medical advice

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This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.