Buserelin

Also known as: Suprefact, Suprecur

HormonalPHASE 3

Clinical Status

Approved in Europe and Canada — not FDA approved in US.

Mechanism of Action

A GnRH agonist analog that desensitizes pituitary GnRH receptors with continuous use, leading to suppression of gonadotropin secretion and subsequent reduction in sex steroid levels.

Dosing Defaults

Dose

100-500 mcg

Frequency

3x daily (intranasal) or depot every 2-3 months

Administration

Intranasal, subcutaneous, or depot injection

Timing

Morning, afternoon, evening (intranasal)

Food

with or without

Duration

Per treatment protocol

Dose range: 100-900 mcg daily (intranasal) or depot

Multiple daily doses maintain suppressive levels for intranasal form.

Side Effects

•Hot flashes
•Headache
•Nasal irritation
•Decreased libido
•Bone density loss
•Depression

Contraindications & Warnings

⚠Pregnancy
⚠Hormone-dependent cancers (initial flare risk)

•Not medical advice
•Not FDA approved in the US

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This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.