Degarelix

Also known as: Firmagon

HormonalFDA APPROVED

Clinical Status

FDA Approved — advanced prostate cancer.

Mechanism of Action

A GnRH antagonist that immediately blocks GnRH receptors in the pituitary without causing initial testosterone flare. Rapidly reduces LH, FSH, and testosterone levels within days.

Dosing Defaults

Dose

240 mg loading, then 80 mg monthly

Frequency

Monthly (after loading dose)

Administration

Subcutaneous injection (abdomen)

Timing

Clinic visit

Food

with or without

Duration

Per oncology protocol

Dose range: 80-240 mg per injection

Monthly depot injection — timing within day is not critical.

Side Effects

•Injection site reactions (40%)
•Hot flashes
•Weight gain
•Fatigue
•Elevated liver enzymes
•QT prolongation

Contraindications & Warnings

⚠Severe hepatic impairment
⚠QT prolongation

•Not medical advice
•Monitor liver function and ECG

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This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.