Exenatide

Also known as: Byetta, Bydureon

Weight LossFDA APPROVED

Clinical Status

FDA Approved — Type 2 diabetes.

Mechanism of Action

Synthetic version of exendin-4 (from Gila monster venom). Acts as a GLP-1 receptor agonist with resistance to DPP-4 degradation. Enhances insulin secretion, suppresses glucagon, and slows gastric emptying.

Dosing Defaults

Dose

5-10 mcg (Byetta) or 2 mg (Bydureon)

Frequency

2x daily or once weekly

Administration

Subcutaneous injection

Timing

60 minutes before meals (Byetta)

Food

fasted

Duration

Long-term use

Dose range: 5-10 mcg twice daily or 2 mg weekly

Pre-meal dosing (short-acting) maximizes post-prandial glucose control.

Side Effects

•Nausea
•Vomiting
•Diarrhea
•Injection site nodules (extended-release)
•Headache
•Pancreatitis

Contraindications & Warnings

⚠Personal/family history of medullary thyroid carcinoma
⚠Severe renal impairment

•Not medical advice
•BOXED WARNING: Thyroid C-cell tumors (extended-release)

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This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.