Exendin-4

Also known as: Exenatide precursor, Gila monster peptide

Pain & AnalgesicPRECLINICAL

Clinical Status

Preclinical for pain — exenatide (derivative) is FDA approved for diabetes.

Mechanism of Action

A 39-amino-acid peptide from Heloderma suspectum (Gila monster) venom. Beyond GLP-1 activity, research shows it has neuroprotective and anti-inflammatory effects in pain pathways, reducing neuroinflammation in dorsal root ganglia.

Dosing Defaults

Dose

5-10 mcg

Frequency

1-2x daily

Administration

Subcutaneous injection

Timing

Morning

Food

fasted

Duration

4-8 weeks

Dose range: 5-20 mcg daily

Morning fasted dosing optimizes bioavailability.

Side Effects

•Nausea
•Vomiting
•Diarrhea
•Headache
•Hypoglycemia
•Injection site reactions

Contraindications & Warnings

⚠Severe renal impairment

•Not medical advice
•Pain indication is preclinical only

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This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.