Ziconotide

Also known as: Prialt, SNX-111

Pain & AnalgesicFDA APPROVED

Clinical Status

FDA Approved — severe chronic pain (intrathecal).

Mechanism of Action

A synthetic peptide derived from cone snail venom (Conus magus). Selectively blocks N-type voltage-gated calcium channels (Cav2.2) in spinal cord dorsal horn neurons, preventing pain signal transmission without opioid receptor involvement.

Dosing Defaults

Dose

0.1-2.4 mcg/day (intrathecal)

Frequency

Continuous intrathecal infusion

Administration

Intrathecal pump

Timing

Continuous

Food

with or without

Duration

Long-term for chronic pain

Dose range: 0.1-19.2 mcg/day intrathecal infusion

Continuous infusion maintains constant analgesic levels in CSF.

Side Effects

•Dizziness
•Nausea
•Confusion
•Headache
•Nystagmus
•Memory impairment
•Psychosis (at higher doses)
•Meningitis risk (from pump)

Contraindications & Warnings

⚠Psychosis
⚠Infection at injection site
⚠Uncontrolled bleeding

•Not medical advice
•BOXED WARNING: Severe psychiatric symptoms
•Requires implanted intrathecal pump

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This information is for educational purposes only and is not medical advice. Dosing data is based on research literature and community reports. Always consult a qualified healthcare provider before using any peptide.